Endocrine Abstracts

A 55 year old man was seen in an endocrinology clinic for possible diagnosis of Cushing’s syndrome. He described a 6 months history of feeling lethargic and increased facial puffiness and abdominal fat. There Cushingoid signs on examination, namely; moon facies, thin skin and bruises with increased abdominal fat distribution. He was admitted to hospital following symptomatic hyperglycaemia and hypokalaemia (lowest reading 2.7 mmol/l). Initial laboratory results showed rai...

A 74-year-old with a history of type 2 diabetes, chronic kidney disease, vitamin D deficiency and bronchiectasis was referred to the medical team with symptomatic hypercalcaemia with raised adjusted calcium of 3.80 mmol/l. Investigations also showed raised creatinine and vitamin D levels; normal parathyroid hormone (PTH) and angiotensin-converting enzyme (ACE). Myeloma screen was negative. A diagnosis of primary hyperparathyroidism was made in view of elevated calcium and norm...

Background: The management of Cushing’s disease can be challenging especially when patients can present with sepsis and severely immunocompromised with limited oral medications to achieve cortisol control. We review a case of Cushing’s disease and the medical management of Cushing’s disease.Case Report: A 54 year old female presented with symptomatic hyperglycaemia with truncal obesity, proximal muscle weakness, right posterior thorax haem...

Introduction: Peptide immunotherapy has been shown to be a simple and effective method of restoring tolerance and reversing disease in animal models of type 1 diabetes. It is highly important to administer the peptide interadermally into an environment in which antigen presenting cells such as dendritic cells are maintained in a tolerogenic state.Objective: Our aim was to determine whether topical pre-treatment of the skin has the potential to enhance to...